The Prodrug Approach: A Successful Tool for Improving Drug Solubility.
نویسندگان
چکیده
Prodrug design is a widely known molecular modification strategy that aims to optimize the physicochemical and pharmacological properties of drugs to improve their solubility and pharmacokinetic features and decrease their toxicity. A lack of solubility is one of the main obstacles to drug development. This review aims to describe recent advances in the improvement of solubility via the prodrug approach. The main chemical carriers and examples of successful strategies will be discussed, highlighting the advances of this field in the last ten years.
منابع مشابه
Mutual Prodrug Concept: Fundamentals and Applications
A therapeutically significant drug may have limited utilization in clinical practice because of poor organoleptic properties, poor bioavailability, short duration of action, nonspecificity, incomplete absorption, poor aqueous solubility, high first-pass metabolism or other adverse effects. There is a great emphasis on research to discover methods aimed at improving their therapeutic efficacy by...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملSolid Dispersion Approach Improving Dissolution Rate of Stiripentol: a Novel Antiepileptic Drug
Some drugs have low bioavailability due to their poor aqueous solubility and/or slowdissolution rate in biological fluids. Stiripentol (STP) is a novel anticonvulsant drug that isstructurally unrelated to the currently available antiepileptics. It has poor aqueous solubilityand its solubility has to be enhanced accordingly. Polyethyleneglycol 6000 (PEG-6000) iscommonly utilized as a hydrophilic...
متن کاملPolymer-Based Prodrugs for Cancer Chemotherapy
Chemotherapy has achieved great success in cancer treatment during recent past decades, but it is still challenged by poor solubility, low tumor selectivity, and associated toxicity of most anticancer drugs. The prodrug strategy is one of the most commonly used chemical/biochemical strategies towards improving the therapeutic index of anticancer drugs. A prodrug is defined as a chemically modif...
متن کاملHydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin
The term prodrug was first used by Albert [1]. Prodrug can be defined as an agent that is transformed after administration, either by metabolism or by spontaneous chemical breakdown, to form a pharmacologically active drug. The prodrug itself is inactive or less active and is converted to active agent in vivo. Targeted prodrug approach is one of the new trends in the treatment of cancer. A lot ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Molecules
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2015